Polynucleotides

Polynucleotides don’t contain hyaluronic acid like fillers do. Instead, they are comprised of biopolymers DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) . In DNA there are two spiral chains of polynucleotide which are arranged in a helical fashion, while RNA is a single-stranded molecule 

Before the treatment a numbing cream can be applied to the patient, especially if there are multiple injections involved. Depending on the area of treatment, the polynucleotides can be injected via two methods. The first are very tiny needles, leaving tiny blebs on the surface which disappear usually after a few hours. Alternatively, a blunt-ended cannula may be used to spread the product evenly. The process usually takes about 20-30 minutes. 

Results last around six to nine months on average, depending on the patient’s lifestyle and rate of ageing. 

The risks of polynucleotides are less than those of other injectable procedures, but this will depend on the practitioner’s experience and technique. However, unlike dermal filler, the treatment cannot be reversed as the product can’t be dissolved.

Side effects of polynucleotides are generally minimal, with the main potential side effects relating to the site of the injection, where patients may experience redness, swelling and bruising which should settle after one to two days. More serious side effects, such as allergic reactions, are extremely rare. As with all treatments, it’s important to carry out a thorough pre-treatment consultation to assess the patient’s suitability.

Unlike with dermal fillers, which have an instant effect, patients won’t notice the full benefits with polynucleotides immediatlely. This is because the action is at the cellular level and it takes time to become apparent, but patients may see some improvement after two to three weeks. 

Although polynucleotides are well tolerated by most patients and are suitable for all skin types, including sensitive skin, they are derived from fish, therefore are not appropriate for vegans. Allergic reactions are very unlikely as the particles of DNA are highly purified, so it can be safely injected into those who have allergies, including seafood allergies, with clinical trials reporting no allergic reactions to date. Polynucleotides are not suitable for patients who are pregnant or intending pregnancy, or who are breastfeeding. 

Patients can generally return to normal activities straight after treatment.

In terms of aftercare, no makeup is advised for 12 hours and no laser treatments or excess heat for three weeks. SPF should be applied strictly for two to three weeks, and sunlight avoided.